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Bupropion-containing products patients should be made aware that bupropion hydrochloride extended-release tablets xl contain the same active ingredient found in zyban , used as an aid to smoking cessation treatment, and that bupropion hydrochloride extended-release tablets xl should not be used in combination with zyban , or any other medications that contain bupropion such as wellbutrin sr bupropion hydrochloride extended-release tablets sr , the sustained-release formulation, or wellbutrin bupropion hydrochloride tablets , the immediate-release formulation.
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following oral administration of a single 150 mg dose of zyban, there were no statistically significant differences in c max , half life, t max , auc, or clearance of bupropion or its major metabolites between smokers and nonsmokers.