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Although clinical studies have shown that desvenlafaxine does not have a clinically relevant effect on cyp2d6 inhibition at doses of 100 mg day, the manufacturer recommends that primary substrates of cyp2d6, such as propranolol, metoprolol, or nebivolol, be dosed at the original level when co-administered with desvenlafaxine 100 mg or lower or when desvenlafaxine is discontinued.
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Oral metoprolol immediate release initiated within the first 24 hours is recommended in all other patients.
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